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Hannes Mikula

Assistant Prof. Dipl.-Ing. Dr.techn.

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+43 1 58801 - 163721
+43 1 58801 - 163 99

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After finishing his studies in Technical Chemistry, Hannes obtained his PhD from TU Wien in 2014. Inspired by the emerging field of bioorthogonal chemistry, he then joined the lab of Prof. Ralph Weissleder at the Massachusetts General Hospital & Harvard Medical School as a postdoctoral fellow funded by the Austrian Science Fund (FWF, Schrödinger Fellowship). In 2016, Hannes returned to TU Wien supported by the FWF (Schrödinger return phase) as an independent young principal investigator. Hannes currently leads the group ‘Molecular Chemistry & Chemical Biology’ at the Institute of Applied Synthetic Chemistry. His team mainly focuses on the development of bioorthogonal tools and reactions for in vivo chemistry, diagnostic tools, medical imaging, and theranostic applications.


  • Bioorthogonal Chemistry
    Development of new chemical tools and reactions to advance the field of click, bioorthogonal & in vivo chemistry; Enhancing bioorthogonal tools by unraveling the underlying molecular mechanisms
  • Diagnostic tools - in vitro assays
    Design of substrates, methods and strategies for LC-MS/MS based diagnostics (e.g. newborn screening of rare diseases), and development of assays for therapeutic drug monitoring (e.g. 'last resort' antibiotics)
  • Diagnostic tools - in vivo medical imaging
    New diagnostic imaging strategies based on in vivo click chemistry (pretargeted molecular imaging, development of bioorthogonal tools radiolabeled with PET nuclides, e.g.fluorine-18)
  • Bioorthogonal drug targeting strategies
    Development of new paradigms to safely and selectively deliver and/or activate drugs in target tissue/cells by applying new bioorthogonal strategies
  • Radiotheranostics
    Combination of diagnostic and therapeutic radionuclides to design bioorthgonal theranostic strategies



  • 2021   START Award, Austrian Science Fund (FWF)
  • 2020   Science Award (Wissenschaftspreis), Austrian Chemical Society (GÖCH) & Austrian Academy of Sciences (ÖAW)
  • 2019   Dream Chemistry Top 5 Award, IOCB Prague & IChF-PAN
  • 2019   ASciNA Young Scientist Award, ASciNA & Federal Ministry of Education, Science and Research, Austria
  • 2015   Karl Schlögl Award, Austrian Academy of Sciences (ÖAW)
  • 2015   Postdoctoral Award (Habilitationspreis), Austrian Chemical Society (GÖCH)
  • 2014   Schrödinger Fellowship, Austrian Science Fund (FWF)
  • 2014   Promotio sub auspiciis Praesidentis rei publicae (PhD with highest distinction)
  • 2014   Excellence Scholarship, Federal Ministry of Science, Research and Economy, Austria
  • 2014   PhD Thesis Award (Dissertationspreis), Austrian Chemical Society (GÖCH)
  • 2014   Appreciation Award (Würdigungspreis), Federal Ministry of Science, Research and Economy, Austria
  • 2013   T. Kery Award, Kery Foundation, Burgenland, Austria
  • 2011   T. Körner Award, Theodor Körner Fund, presented by the Federal President of Austria
  • 2008   Diploma Thesis Award of the City of Vienna, Austria